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Guide for FPGEE: Foreign Pharmacy Graduate Equivalency Examination

Quiz FPGEE: Foreign Pharmacy Graduate Equivalency Examination

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/ 10

Quiz

1/10
In a zero order elimination process, which of the following is true?
Select the answer
1 correct answer
A.
The removal of drug is independent of drug concentration
B.
Cl = Elimination rate/Cp
C.
t1/2 = .7VD/Cl
D.
All are true

Quiz

2/10
For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?
Select the answer
1 correct answer
A.
Excretion rate
B.
Metabolism rate
C.
Absorption rate
D.
Distribution rate
E.
All of the above

Quiz

3/10
Bioavailability is related to which of the following parameters, according to the equation F = 1 - E
Select the answer
1 correct answer
A.
Excretion
B.
Elimination
C.
Extraction Ratio
D.
Enterohepatic Recycling

Quiz

4/10
For the majority of drugs, which of the following equations correctly defines clearance?
Select the answer
1 correct answer
A.
Cl = Elimination rate/Cp
B.
Cl = QxE
C.
Cl = .7VD/t1/2
D.
All are correct

Quiz

5/10
How much of a 10 mg dose of morphine reaches the systemic circulation given F = .24?
Select the answer
1 correct answer
A.
24mg
B.
0.24 mg
C.
2.4 mg
D.
4.1 mg

Quiz

6/10
Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a
10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?
Select the answer
1 correct answer
A.
5 mg
B.
2.5 mg
C.
1.25 mg
D.
625 mg

Quiz

7/10
Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal
hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given
in the previous question is entirely hepatic clearance.
Select the answer
1 correct answer
A.
30 L/hr/70 Kg
B.
60 L/hr/70 Kg
C.
120 L/hr/70 Kg
D.
250 L/hr/70 Kg

Quiz

8/10
Which of the following enzymes could directly act on codeine?
Select the answer
1 correct answer
A.
Glucuronyl transferase
B.
Sulfotransferase
C.
Glutathione transferase
D.
A & B
E.
All of the above

Quiz

9/10
Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
Select the answer
1 correct answer
A.
CYP1A2
B.
CYP2C9
C.
CYP3A4
D.
CYP51
E.
All are drug metabolizing isoforms

Quiz

10/10
Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?
Select the answer
1 correct answer
A.
CYP1A2
B.
CYP2C9
C.
CYP2D6
D.
CYP3A4
E.
CYP51
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  • Quiz name:FPGEE: Foreign Pharmacy Graduate Equivalency Examination
  • Total number of questions:426
  • Number of questions for the test:50
  • Pass score:80%

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